Role of P2X Purinoceptor 7 in Neurogenic Pulmonary Edema after Subarachnoid Hemorrhage in Rats
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منابع مشابه
Role of P2X Purinoceptor 7 in Neurogenic Pulmonary Edema after Subarachnoid Hemorrhage in Rats
INTRODUCTION Neurogenic pulmonary edema (NPE) is an acute and serious complication after subarachnoid hemorrhage (SAH) with high mortality. The present study aimed to test the therapeutic potential of brilliant blue G (BBG), a selective P2X purinoceptor 7 (P2X7R) antagonist, on NPE in a rat SAH model. METHODS SAH was induced by endovascular perforation. 86 Sprague-Dawley rats were randomly di...
متن کاملSubarachnoid hemorrhage and hydrocephalus causing neurogenic pulmonary edema.
Division of Neurological Surgery, University of São Paulo School of Medicine, São Paulo SP, Brazil: MD, PhD, Supervisor, Head of Cerebrovacular Surgery; MD, Resident; Student of Medicine, Federal University of Bahia; MD, PhD, Chairman and Director. Neurogenic pulmonary edema (NPE) is described as the acute onset of dyspnea or a decrease in PaO2/FiO2 ratio caused by a pulmonary interstitial and ...
متن کاملHistopathologic evaluation of neurogenic pulmonary edema after subarachnoid hemorrhage in rabbits.
OBJECTIVE To investigate the effects of subarachnoid hemorrhage (SAH) on lung tissue. METHODS We conducted this study on 20 rabbits in the Ataturk University Medical Faculty, Erzurum, Turkey in 2005. Experimental SAH was applied to all animals under general anesthesia. After 20 days, all animals were sacrificed. Their lungs were examined histopathologically. RESULTS Foamy hemorrhagic parenc...
متن کاملCaspase-1 inhibitor prevents neurogenic pulmonary edema after subarachnoid hemorrhage in mice.
BACKGROUND AND PURPOSE We examined the effects of a caspase-1 inhibitor, N-Ac-Tyr-Val-Ala-Asp-chloromethyl ketone (Ac-YVAD-CMK), on neurogenic pulmonary edema in the endovascular perforation model of subarachnoid hemorrhage (SAH) in mice. METHODS Ninety-seven mice were assigned to sham, SAH+vehicle, SAH+Ac-YVAD-CMK (6 or 10 mg/kg), and SAH+Z-Val-Ala-Asp-fluoromethylketone (Z-VAD-FMK, 6 mg/kg)...
متن کاملEndovascular Treatment for Aneurysmal Subarachnoid Hemorrhage with Neurogenic Pulmonary Edema in the Acute Stage.
AIM Severe neurogenic pulmonary edema (NPE) can occur in a variety of brain insults, including subarachnoid hemorrhage (SAH), and severe case of NPE can cause devastating consequences. But the literature on the treatment strategy about aneurysmal SAH with NPE is very scant. We present that SAH patients with severe NPE, who were treated first by embolization of aneurysm followed by insertion of ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0089042